4-[(6-oxo-1,6-dihydropyrimidin-2-yl)amino]benzonitrile

Name	4-N[2(4-hydroxypyrimidinyl)]Aminobenzonitrile
Synonyms	4-((4-Oxo-1,4-dihydropyrimidin-2-yl) 4-N[2(4-hydroxypyrimidinyl)]Aminobenzonitrile 4-[(4-Hydroxy-pyrimidin-2-yl)amino]-benzonitr 4-N[2(4-HYDROXYPYRIMIDINYL)]AMINOBENZONITRILE 4-N[2(4-hydroxypyrimidinyl)]aminobenzonnitrile 4-[(6-oxo-1H-pyrimidin-2-yl)amino]benzonitrile 4-[(4-Hydroxy-2-pyrimidinyl)amino]benzonitrile 4-[(6-oxo-1,6-dihydropyrimidin-2-yl)amino]benzonitrile 4-[(1,4-dihydro-4-oxo-2-pyrimidinyl)amino]benzonitrile 4-((4-Oxo-1,4-dihydropyriMidin-2-yl)aMino)benzonitrile 4-[(1,4-Dihydro-4-oxo-2-pyrimidinyl)amino]benzonitrile Benzonitrile, 4-[(1,4-dihydro-4-oxo-2-pyriMidinyl)aMino]-
CAS	189956-45-4
InChI	InChI=1/C11H8N4O/c12-7-8-1-3-9(4-2-8)14-11-13-6-5-10(16)15-11/h1-6H,(H2,13,14,15,16)

Molecular Formula	C11H8N4O
Molar Mass	212.21
Density	1.31±0.1 g/cm3(Predicted)
Melting Point	>300°C
Boling Point	399.7°C at 760 mmHg
Flash Point	195.6°C
Solubility	DMSO (Slightly), Methanol (Slightly)
Vapor Presure	0-0Pa at 20-25℃
Appearance	Solid
Color	Pale Brown to Brown
pKa	8.66±0.40(Predicted)
Storage Condition	2-8°C
Refractive Index	1.67

LogP	0.9 at pH6.6
use	4-[(4-hydroxy-2-pyrimidinyl) amino] benzonitrile can be used as an intermediate in organic synthesis and a pharmaceutical intermediate, and can be used in the laboratory Organic synthesis process and chemical and pharmaceutical research and development process.
preparation	weigh 2-(methylthio) pyrimidine -4(3H)-one (3g,21mmol) and 4-aminobenzonitrile (2.99g,25mmol) in a 50mL round bottom flask, protected by nitrogen, slowly heated to 180 ℃, and reacted for 8 hours. After the reaction is cooled, 20mL of acetonitrile is added for ultrasonic treatment, filtration, the filter cake is washed with acetonitrile, no 4-aminobenzonitrile residue is detected by TLC, and the light yellow solid obtained by drying the filter cake is 4-((4-oxo -1, 6-dihydropyrimidine -2-yl) amino) benzonitrile with a yield of 73.6%.

Last Update：2024-04-09 02:00:07

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Product Name: 4-[(4-Hydroxy-2-pyrimidinyl)amino]benzonitrile Request for quotation
CAS: 189956-45-4
Tel: +86-571-88162785
Email: Lucy@verypharm.com
Mobile: +86-13606544505
QQ: 472954302

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4-[(6-oxo-1,6-dihydropyrimidin-2-yl)amino]benzonitrile Request for Quotation